Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis

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Serval ID
serval:BIB_4C55C8B1D132
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis
Journal
Journal of Experimental Medicine
Author(s)
Vincent  M. S., Roessner  K., Lynch  D., Wilson  D., Cooper  S. M., Tschopp  J., Sigal  L. H., Budd  R. C.
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
12/1996
Volume
184
Number
6
Pages
2109-17
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 1
Abstract
The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial gamma delta T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that gamma delta T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process.
Keywords
*Antigens, CD95 *Apoptosis Arthritis, Infectious/*immunology Borrelia burgdorferi Group/*immunology CD4-Positive T-Lymphocytes/*immunology/microbiology CD8-Positive T-Lymphocytes/immunology Clone Cells DNA Primers Flow Cytometry Humans Immunophenotyping Lyme Disease/*immunology Lymphocyte Activation Polymerase Chain Reaction Receptors, Antigen, T-Cell, gamma-delta/analysis/biosynthesis/*immunology Synovial Fluid/*immunology T-Lymphocyte Subsets/*immunology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:19
Last modification date
20/08/2019 14:00
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