Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Molecular mechanisms of virulence in fungus-host interactions for Aspergillus fumigatus and Candida albicans
36 Suppl 1
Research on fungi that cause opportunistic infections has increased dramatically during the past few years, largely because these organisms cause significant morbidity and mortality. Most of this research has focused on defining the virulence factors produced by these pathogens, as well as developing methods for the diagnosis of fungal diseases. With regard to studies on the biology of Candida albicans, it is now possible to isolate genes, disrupt their expression, and observe the specific effects of gene disruption on virulence and growth of the organism. Moreover, growth and virulence of this pathogen is also being studied and the effect of environmental factors on gene expression investigated. This subject is especially important in view of the fact that C. albicans can colonize and invade a number of sites in the human body. Thus, its ability to grown in the oral and vaginal tracts, as well as in blood, requires the organism to adapt to a variety of environmental stresses. Here we present observations on the growth, morphogenesis and virulence of the opportunistic fungi C. albicans and Aspergillus fumigatus.
Amino Acid Sequence Apoenzymes/genetics Aspergillus fumigatus/enzymology/growth & development/*pathogenicity Candida albicans/enzymology/growth & development/*pathogenicity Deoxyribodipyrimidine Photo-Lyase/genetics *Fungal Proteins Gene Expression Regulation, Fungal Genes, Fungal Humans Hydrogen-Ion Concentration *Membrane Glycoproteins Molecular Sequence Data Virulence/genetics
Web of science
Last modification date