Molecular mechanisms of virulence in fungus-host interactions for Aspergillus fumigatus and Candida albicans

Détails

ID Serval
serval:BIB_4B132B99FE7A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular mechanisms of virulence in fungus-host interactions for Aspergillus fumigatus and Candida albicans
Périodique
Medical Mycology
Auteur⸱e⸱s
Muhlschlegal  F., Fonzi  W., Hoyer  L., Payne  T., Poulet  F. M., Clevenger  J., Latge  J. P., Calera  J., Beauvais  A., Paris  S., Monod  M., Sturtevant  J., Ghannoum  M., Nozawa  Y., Calderone  R.
ISSN
1369-3786 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
36 Suppl 1
Pages
238-48
Notes
Journal Article
Review
Résumé
Research on fungi that cause opportunistic infections has increased dramatically during the past few years, largely because these organisms cause significant morbidity and mortality. Most of this research has focused on defining the virulence factors produced by these pathogens, as well as developing methods for the diagnosis of fungal diseases. With regard to studies on the biology of Candida albicans, it is now possible to isolate genes, disrupt their expression, and observe the specific effects of gene disruption on virulence and growth of the organism. Moreover, growth and virulence of this pathogen is also being studied and the effect of environmental factors on gene expression investigated. This subject is especially important in view of the fact that C. albicans can colonize and invade a number of sites in the human body. Thus, its ability to grown in the oral and vaginal tracts, as well as in blood, requires the organism to adapt to a variety of environmental stresses. Here we present observations on the growth, morphogenesis and virulence of the opportunistic fungi C. albicans and Aspergillus fumigatus.
Mots-clé
Amino Acid Sequence Apoenzymes/genetics Aspergillus fumigatus/enzymology/growth & development/*pathogenicity Candida albicans/enzymology/growth & development/*pathogenicity Deoxyribodipyrimidine Photo-Lyase/genetics *Fungal Proteins Gene Expression Regulation, Fungal Genes, Fungal Humans Hydrogen-Ion Concentration *Membrane Glycoproteins Molecular Sequence Data Virulence/genetics
Pubmed
Web of science
Création de la notice
25/01/2008 16:46
Dernière modification de la notice
20/08/2019 13:58
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