Physiopathologie des anévrismes idiopathiques de l'aorte thoracique ascendante [Pathobiology of idiopathic ascending aortic aneurysms]
Details
Serval ID
serval:BIB_4AC3D8674B2A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Physiopathologie des anévrismes idiopathiques de l'aorte thoracique ascendante [Pathobiology of idiopathic ascending aortic aneurysms]
Journal
Presse medicale
ISSN
2213-0276 (Electronic)
ISSN-L
0755-4982
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
38
Number
7-8
Pages
1076-1088
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The majority of ascending aortic aneurysms cannot be related to any specific etiology and should be qualified as idiopathic. The incidence of this disease is increasing in the population of the developed countries but its pathobiology is poorly understood.
This article is reviewing the publications concerning the pathobiology of idiopathic ascending aortic aneurysms.
A PubMed search on articles published in English or French, between January 1965 and December 2007, on key-words < aortic root >, < ascending aorta >, < aortic arch >, < thoracic aorta >, < aneurysm >, < dilatation > and < dissection > was undertaken. Articles on aneurysms related to inflammatory and infectious diseases, congenital or genetic syndromes were excluded.
The presented data suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression.
Sparse data available from few direct studies offer limited knowledge on pathobiology of idiopathic ascending aortic aneurysms.
A more intimate knowledge of the triggers and perpetrating factors of this disease might offer new diagnostic and treatment options.
This article is reviewing the publications concerning the pathobiology of idiopathic ascending aortic aneurysms.
A PubMed search on articles published in English or French, between January 1965 and December 2007, on key-words < aortic root >, < ascending aorta >, < aortic arch >, < thoracic aorta >, < aneurysm >, < dilatation > and < dissection > was undertaken. Articles on aneurysms related to inflammatory and infectious diseases, congenital or genetic syndromes were excluded.
The presented data suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression.
Sparse data available from few direct studies offer limited knowledge on pathobiology of idiopathic ascending aortic aneurysms.
A more intimate knowledge of the triggers and perpetrating factors of this disease might offer new diagnostic and treatment options.
Keywords
Aorta/metabolism, Aorta/physiopathology, Aortic Aneurysm, Thoracic/etiology, Aortic Aneurysm, Thoracic/metabolism, Aortic Aneurysm, Thoracic/physiopathology, Aortic Rupture/epidemiology, Collagen/metabolism, Elastic Tissue/metabolism, Genotype, Glycosaminoglycans/metabolism, Humans, Immunoblotting, Matrix Metalloproteinase 1/metabolism, Matrix Metalloproteinase 13/metabolism, Matrix Metalloproteinase 7/metabolism, Matrix Metalloproteinase 9/metabolism, Oligonucleotide Array Sequence Analysis, Point Mutation/genetics
Pubmed
Web of science
Create date
29/03/2019 8:19
Last modification date
20/08/2019 14:58
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