Physiopathologie des anévrismes idiopathiques de l'aorte thoracique ascendante [Pathobiology of idiopathic ascending aortic aneurysms]
Détails
ID Serval
serval:BIB_4AC3D8674B2A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Physiopathologie des anévrismes idiopathiques de l'aorte thoracique ascendante [Pathobiology of idiopathic ascending aortic aneurysms]
Périodique
Presse medicale
ISSN
2213-0276 (Electronic)
ISSN-L
0755-4982
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
38
Numéro
7-8
Pages
1076-1088
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The majority of ascending aortic aneurysms cannot be related to any specific etiology and should be qualified as idiopathic. The incidence of this disease is increasing in the population of the developed countries but its pathobiology is poorly understood.
This article is reviewing the publications concerning the pathobiology of idiopathic ascending aortic aneurysms.
A PubMed search on articles published in English or French, between January 1965 and December 2007, on key-words < aortic root >, < ascending aorta >, < aortic arch >, < thoracic aorta >, < aneurysm >, < dilatation > and < dissection > was undertaken. Articles on aneurysms related to inflammatory and infectious diseases, congenital or genetic syndromes were excluded.
The presented data suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression.
Sparse data available from few direct studies offer limited knowledge on pathobiology of idiopathic ascending aortic aneurysms.
A more intimate knowledge of the triggers and perpetrating factors of this disease might offer new diagnostic and treatment options.
This article is reviewing the publications concerning the pathobiology of idiopathic ascending aortic aneurysms.
A PubMed search on articles published in English or French, between January 1965 and December 2007, on key-words < aortic root >, < ascending aorta >, < aortic arch >, < thoracic aorta >, < aneurysm >, < dilatation > and < dissection > was undertaken. Articles on aneurysms related to inflammatory and infectious diseases, congenital or genetic syndromes were excluded.
The presented data suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression.
Sparse data available from few direct studies offer limited knowledge on pathobiology of idiopathic ascending aortic aneurysms.
A more intimate knowledge of the triggers and perpetrating factors of this disease might offer new diagnostic and treatment options.
Mots-clé
Aorta/metabolism, Aorta/physiopathology, Aortic Aneurysm, Thoracic/etiology, Aortic Aneurysm, Thoracic/metabolism, Aortic Aneurysm, Thoracic/physiopathology, Aortic Rupture/epidemiology, Collagen/metabolism, Elastic Tissue/metabolism, Genotype, Glycosaminoglycans/metabolism, Humans, Immunoblotting, Matrix Metalloproteinase 1/metabolism, Matrix Metalloproteinase 13/metabolism, Matrix Metalloproteinase 7/metabolism, Matrix Metalloproteinase 9/metabolism, Oligonucleotide Array Sequence Analysis, Point Mutation/genetics
Pubmed
Web of science
Création de la notice
29/03/2019 8:19
Dernière modification de la notice
20/08/2019 14:58
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