Studies of Lassa Virus Cell Entry.

Détails

ID Serval
serval:BIB_46014644EC43
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Studies of Lassa Virus Cell Entry.
Périodique
Methods in molecular biology
Auteur(s)
Pasquato A., Fernandez A.H., Kunz S.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
1604
Pages
135-155
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Host cell entry is the first and most fundamental step of every virus infection and represents a major barrier for zoonotic transmission and viral emergence. Targeting viral entry appears further as a promising strategy for therapeutic intervention. Several cellular receptors have been identified for Lassa virus, including dystroglycan, TAM receptor tyrosine kinases, and C-type lectins. Upon receptor binding, LASV enters the host cell via a largely unknown clathrin- and dynamin-independent endocytotic pathway that delivers the virus to late endosomes, where fusion occurs after engagement of a second, intracellular receptor, the late endosomal/lysosomal resident protein LAMP1. Here, we describe a series of experimental approaches to investigate LASV cell entry and to test candidate inhibitors for their action at this early and decisive step of infection.
Mots-clé
Animals, Clathrin/metabolism, Dynamins/metabolism, Endocytosis/genetics, Endocytosis/physiology, Endosomes/metabolism, Humans, Lassa virus/metabolism, Lassa virus/physiology, Lysosomal-Associated Membrane Protein 1/metabolism, Protein Binding, Virus Internalization, Endocytosis, Endosome, Inhibitor, Lassa virus, Receptor, Viral entry
Pubmed
Création de la notice
19/10/2017 15:48
Dernière modification de la notice
25/06/2018 17:32
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