Studies of Lassa Virus Cell Entry.

Détails

ID Serval
serval:BIB_46014644EC43
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Studies of Lassa Virus Cell Entry.
Périodique
Methods in molecular biology
Auteur⸱e⸱s
Pasquato A., Fernandez A.H., Kunz S.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
1604
Pages
135-155
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Host cell entry is the first and most fundamental step of every virus infection and represents a major barrier for zoonotic transmission and viral emergence. Targeting viral entry appears further as a promising strategy for therapeutic intervention. Several cellular receptors have been identified for Lassa virus, including dystroglycan, TAM receptor tyrosine kinases, and C-type lectins. Upon receptor binding, LASV enters the host cell via a largely unknown clathrin- and dynamin-independent endocytotic pathway that delivers the virus to late endosomes, where fusion occurs after engagement of a second, intracellular receptor, the late endosomal/lysosomal resident protein LAMP1. Here, we describe a series of experimental approaches to investigate LASV cell entry and to test candidate inhibitors for their action at this early and decisive step of infection.
Mots-clé
Animals, Clathrin/metabolism, Dynamins/metabolism, Endocytosis/genetics, Endocytosis/physiology, Endosomes/metabolism, Humans, Lassa virus/metabolism, Lassa virus/physiology, Lysosomal-Associated Membrane Protein 1/metabolism, Protein Binding, Virus Internalization, Endocytosis, Endosome, Inhibitor, Lassa virus, Receptor, Viral entry
Pubmed
Création de la notice
19/10/2017 14:48
Dernière modification de la notice
20/08/2019 13:51
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