Article: article from journal or magazin.
Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.
Brain Research. Developmental Brain Research
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May 20
Tetrodotoxin was injected into one eye of chick embryos so as to block activity in the target territory of the isthmo-optic nucleus (ION) during its period of neuronal death. This markedly reduced the neuronal death and thereby prolonged the survival of some 'aberrantly' projecting neurons which would normally all die. In addition, the cytoarchitecture of the ION developed abnormally. Since these two effects differ markedly in their dose-dependence and in other ways, they cannot both be explained by changes in the strength of a single retrograde signal.
Animals, Axons/drug effects, Brain/cytology, Brain/drug effects, Carbocyanines/diagnostic use, Cell Death/drug effects, Chick Embryo, Electric Stimulation, Electrophysiology, Neurons/drug effects, Retina/physiology, Tetrodotoxin/pharmacology
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