Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.

Détails

ID Serval
serval:BIB_4568F3083EE0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.
Périodique
Brain Research. Developmental Brain Research
Auteur(s)
Péquignot Y., Clarke P.G.H.
ISSN
0165-3806[print], 0165-3806[linking]
Statut éditorial
Publié
Date de publication
1991
Volume
60
Numéro
1
Pages
94-98
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May 20
Résumé
Tetrodotoxin was injected into one eye of chick embryos so as to block activity in the target territory of the isthmo-optic nucleus (ION) during its period of neuronal death. This markedly reduced the neuronal death and thereby prolonged the survival of some 'aberrantly' projecting neurons which would normally all die. In addition, the cytoarchitecture of the ION developed abnormally. Since these two effects differ markedly in their dose-dependence and in other ways, they cannot both be explained by changes in the strength of a single retrograde signal.
Mots-clé
Animals, Axons/drug effects, Brain/cytology, Brain/drug effects, Carbocyanines/diagnostic use, Cell Death/drug effects, Chick Embryo, Electric Stimulation, Electrophysiology, Neurons/drug effects, Retina/physiology, Tetrodotoxin/pharmacology
Pubmed
Création de la notice
20/01/2008 18:49
Dernière modification de la notice
20/08/2019 14:50
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