Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.

Details

Serval ID
serval:BIB_4568F3083EE0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.
Journal
Brain Research. Developmental Brain Research
Author(s)
Péquignot Y., Clarke P.G.H.
ISSN
0165-3806[print], 0165-3806[linking]
Publication state
Published
Issued date
1991
Volume
60
Number
1
Pages
94-98
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May 20
Abstract
Tetrodotoxin was injected into one eye of chick embryos so as to block activity in the target territory of the isthmo-optic nucleus (ION) during its period of neuronal death. This markedly reduced the neuronal death and thereby prolonged the survival of some 'aberrantly' projecting neurons which would normally all die. In addition, the cytoarchitecture of the ION developed abnormally. Since these two effects differ markedly in their dose-dependence and in other ways, they cannot both be explained by changes in the strength of a single retrograde signal.
Keywords
Animals, Axons/drug effects, Brain/cytology, Brain/drug effects, Carbocyanines/diagnostic use, Cell Death/drug effects, Chick Embryo, Electric Stimulation, Electrophysiology, Neurons/drug effects, Retina/physiology, Tetrodotoxin/pharmacology
Pubmed
Create date
20/01/2008 18:49
Last modification date
03/03/2018 16:45
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