Malarial hemozoin is a Nalp3 inflammasome activating danger signal
Details
Serval ID
serval:BIB_45304BF7774B
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Malarial hemozoin is a Nalp3 inflammasome activating danger signal
Title of the conference
Advances in TNF family research
Publisher
Springer
Organization
Proceedings of the 12th International TNF Conference, 2009
Address
Berlin
ISBN
978-1-4419-6611-7
Publication state
Published
Issued date
2011
Editor
Wallach D., Kovalenko A., Feldman M.
Volume
691
Series
Advances in Experimental Medicine and Biology
Pages
672-672
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a pigment called hemozoin that is generated by detoxification of heme after hemoglobin degradation in infected red blood cells. We will present data showing that hemoroin acts as a proinflammatory danger signal through activation of the Nalp3 inflammasome, causing the release of IL-1β. Similar to other Nalp3-activating particles, hemozoin activity is blocked by inhibitors of phagocytosis, K+ efflux and NADPH oxidase. In vivo, injection of hemozoin results in acute peritonitis, which is impaired in Nalp3- and IL-1R-deficient mice. Moreover, the pathogenesis of cerebral malaria is reduced in caspase-1-deficient mice infected with Plasmodium berghei sporozoites, while parasitemia remains unchanged. Thus, Plasmodium-generated hemozoin may act as a danger signal resulting in an uncontrolled proinflammatory host response and thereby contributing to the cerebral manifestations seen in malaria.
Web of science
Create date
02/09/2011 10:06
Last modification date
20/08/2019 14:49