Malarial hemozoin is a Nalp3 inflammasome activating danger signal

Details

Serval ID
serval:BIB_45304BF7774B
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Malarial hemozoin is a Nalp3 inflammasome activating danger signal
Title of the conference
Advances in TNF family research
Author(s)
Tschopp J.
Publisher
Springer
Organization
Proceedings of the 12th International TNF Conference, 2009
Address
Berlin
ISBN
978-1-4419-6611-7
Publication state
Published
Issued date
2011
Editor
Wallach D., Kovalenko A., Feldman M.
Volume
691
Series
Advances in Experimental Medicine and Biology
Pages
672-672
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a pigment called hemozoin that is generated by detoxification of heme after hemoglobin degradation in infected red blood cells. We will present data showing that hemoroin acts as a proinflammatory danger signal through activation of the Nalp3 inflammasome, causing the release of IL-1β. Similar to other Nalp3-activating particles, hemozoin activity is blocked by inhibitors of phagocytosis, K+ efflux and NADPH oxidase. In vivo, injection of hemozoin results in acute peritonitis, which is impaired in Nalp3- and IL-1R-deficient mice. Moreover, the pathogenesis of cerebral malaria is reduced in caspase-1-deficient mice infected with Plasmodium berghei sporozoites, while parasitemia remains unchanged. Thus, Plasmodium-generated hemozoin may act as a danger signal resulting in an uncontrolled proinflammatory host response and thereby contributing to the cerebral manifestations seen in malaria.
Web of science
Create date
02/09/2011 9:06
Last modification date
20/08/2019 13:49
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