Malarial hemozoin is a Nalp3 inflammasome activating danger signal
Détails
ID Serval
serval:BIB_45304BF7774B
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Malarial hemozoin is a Nalp3 inflammasome activating danger signal
Titre de la conférence
Advances in TNF family research
Editeur
Springer
Organisation
Proceedings of the 12th International TNF Conference, 2009
Adresse
Berlin
ISBN
978-1-4419-6611-7
Statut éditorial
Publié
Date de publication
2011
Editeur⸱rice scientifique
Wallach D., Kovalenko A., Feldman M.
Volume
691
Série
Advances in Experimental Medicine and Biology
Pages
672-672
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a pigment called hemozoin that is generated by detoxification of heme after hemoglobin degradation in infected red blood cells. We will present data showing that hemoroin acts as a proinflammatory danger signal through activation of the Nalp3 inflammasome, causing the release of IL-1β. Similar to other Nalp3-activating particles, hemozoin activity is blocked by inhibitors of phagocytosis, K+ efflux and NADPH oxidase. In vivo, injection of hemozoin results in acute peritonitis, which is impaired in Nalp3- and IL-1R-deficient mice. Moreover, the pathogenesis of cerebral malaria is reduced in caspase-1-deficient mice infected with Plasmodium berghei sporozoites, while parasitemia remains unchanged. Thus, Plasmodium-generated hemozoin may act as a danger signal resulting in an uncontrolled proinflammatory host response and thereby contributing to the cerebral manifestations seen in malaria.
Web of science
Création de la notice
02/09/2011 10:06
Dernière modification de la notice
20/08/2019 14:49