Evidence for an episodic model of protein sequence evolution.

Details

Serval ID
serval:BIB_43CBA0DC9689
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evidence for an episodic model of protein sequence evolution.
Journal
Biochemical Society transactions
Author(s)
Studer R.A., Robinson-Rechavi M.
ISSN
1470-8752[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
37
Number
Pt 4
Pages
783-786
Language
english
Abstract
The evolution of protein function appears to involve alternating periods of conservative evolution and of relatively rapid change. Evidence for such episodic evolution, consistent with some theoretical expectations, comes from the application of increasingly sophisticated models of evolution to large sequence datasets. We present here some of the recent methods to detect functional shifts, using amino acid or codon models. Both provide evidence for punctual shifts in patterns of amino acid conservation, including the fixation of key changes by positive selection. Although a link to gene duplication, a presumed source of functional changes, has been difficult to establish, this episodic model appears to apply to a wide variety of proteins and organisms.
Keywords
codon model, functional divergence, positive selection, protein evolution
Pubmed
Web of science
Create date
19/05/2009 9:44
Last modification date
20/08/2019 14:47
Usage data