Evidence for an episodic model of protein sequence evolution.

Détails

ID Serval
serval:BIB_43CBA0DC9689
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence for an episodic model of protein sequence evolution.
Périodique
Biochemical Society transactions
Auteur(s)
Studer R.A., Robinson-Rechavi M.
ISSN
1470-8752[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
37
Numéro
Pt 4
Pages
783-786
Langue
anglais
Résumé
The evolution of protein function appears to involve alternating periods of conservative evolution and of relatively rapid change. Evidence for such episodic evolution, consistent with some theoretical expectations, comes from the application of increasingly sophisticated models of evolution to large sequence datasets. We present here some of the recent methods to detect functional shifts, using amino acid or codon models. Both provide evidence for punctual shifts in patterns of amino acid conservation, including the fixation of key changes by positive selection. Although a link to gene duplication, a presumed source of functional changes, has been difficult to establish, this episodic model appears to apply to a wide variety of proteins and organisms.
Mots-clé
codon model, functional divergence, positive selection, protein evolution
Pubmed
Web of science
Création de la notice
19/05/2009 8:44
Dernière modification de la notice
20/08/2019 13:47
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