Article: article from journal or magazin.
NKT cells: In the beginning...
European Journal of Immunology
37 Suppl 1
Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.
Allergy and Immunology/history, Animals, Cytotoxicity, Immunologic, History, 20th Century, Humans, Killer Cells, Natural/immunology, Receptors, Antigen, T-Cell/genetics, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
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