NKT cells: In the beginning...

Details

Serval ID
serval:BIB_43AB15E1C640
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NKT cells: In the beginning...
Journal
European Journal of Immunology
Author(s)
Macdonald H.R.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
37 Suppl 1
Pages
S111-S115
Language
english
Abstract
Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.
Keywords
Allergy and Immunology/history, Animals, Cytotoxicity, Immunologic, History, 20th Century, Humans, Killer Cells, Natural/immunology, Receptors, Antigen, T-Cell/genetics, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2010 14:49
Last modification date
20/08/2019 14:47
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