NKT cells: In the beginning...

Détails

ID Serval
serval:BIB_43AB15E1C640
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
NKT cells: In the beginning...
Périodique
European Journal of Immunology
Auteur⸱e⸱s
Macdonald H.R.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
37 Suppl 1
Pages
S111-S115
Langue
anglais
Résumé
Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.
Mots-clé
Allergy and Immunology/history, Animals, Cytotoxicity, Immunologic, History, 20th Century, Humans, Killer Cells, Natural/immunology, Receptors, Antigen, T-Cell/genetics, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/02/2010 14:49
Dernière modification de la notice
20/08/2019 14:47
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