Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 17/06/2020.
Etat: Public
Version: Author's accepted manuscript
Licence: CC BY 4.0
Document(s) secondaire(s)
Sous embargo jusqu'au 17/06/2020.
Etat: Public
Version: Supplementary document
Licence: CC BY 4.0
ID Serval
serval:BIB_42894FBE4719
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.
Périodique
Nature neuroscience
Auteur(s)
Valentinova K., Tchenio A., Trusel M., Clerke J.A., Lalive A.L., Tzanoulinou S., Matera A., Moutkine I., Maroteaux L., Paolicelli R.C., Volterra A., Bellone C., Mameli M.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
22
Numéro
7
Pages
1053-1056
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.
Mots-clé
Adaptation, Psychological, Animals, Cytokines/physiology, Female, Habenula/physiology, Male, Mice, Mice, Inbred C57BL, Microglia/physiology, Morphine/adverse effects, Naloxone/toxicity, Neuronal Plasticity, Random Allocation, Receptors, Glutamate/analysis, Receptors, N-Methyl-D-Aspartate/analysis, Receptors, Tumor Necrosis Factor, Type I/genetics, Receptors, Tumor Necrosis Factor, Type I/physiology, Social Behavior, Substance Withdrawal Syndrome/physiopathology, Substance Withdrawal Syndrome/psychology, Synaptic Transmission/physiology, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Création de la notice
24/06/2019 17:41
Dernière modification de la notice
20/08/2019 14:45
Données d'usage