Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Valentinova, K.; Tchenio, A.; Trusel, M.; Clerke, J.A.; Lalive, A.L.; Tzanoulinou, S.; Matera, A.; Moutkine, I.; Maroteaux, L.; Paolicelli, R.C.; Volterra, A.; Bellone, C.; Mameli, M.

doi:10.1038/s41593-019-0421-4

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Détails

Télécharger: 31209376_cover.pdf (3059.44 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Tous droits réservés

Document(s) secondaire(s)

Télécharger: 78956_3_supp_814321_pqr5ch.pdf (557.76 [Ko])
Etat: Public
Version: Supplementary document
Licence: CC BY 4.0

ID Serval

serval:BIB_42894FBE4719

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Périodique

Nature neuroscience

Auteur⸱e⸱s

Valentinova K., Tchenio A., Trusel M., Clerke J.A., Lalive A.L., Tzanoulinou S., Matera A., Moutkine I., Maroteaux L., Paolicelli R.C., Volterra A., Bellone C., Mameli M.

ISSN

1546-1726 (Electronic)

ISSN-L

1097-6256

Statut éditorial

Publié

Date de publication

07/2019

Peer-reviewed

Oui

Volume

Numéro

Pages

1053-1056

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

Mots-clé

Adaptation, Psychological, Animals, Cytokines/physiology, Female, Habenula/physiology, Male, Mice, Mice, Inbred C57BL, Microglia/physiology, Morphine/adverse effects, Naloxone/toxicity, Neuronal Plasticity, Random Allocation, Receptors, Glutamate/analysis, Receptors, N-Methyl-D-Aspartate/analysis, Receptors, Tumor Necrosis Factor, Type I/genetics, Receptors, Tumor Necrosis Factor, Type I/physiology, Social Behavior, Substance Withdrawal Syndrome/physiopathology, Substance Withdrawal Syndrome/psychology, Synaptic Transmission/physiology, Tumor Necrosis Factor-alpha/physiology

URN

urn:nbn:ch:serval-BIB_42894FBE47195

OAI-PMH

oai:serval.unil.ch:BIB_42894FBE4719

DOI

10.1038/s41593-019-0421-4

Pubmed

31209376

Web of science

000472612100005

Création de la notice

24/06/2019 16:41