Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

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Version: Author's accepted manuscript
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Version: Supplementary document
License: CC BY 4.0
Serval ID
serval:BIB_42894FBE4719
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.
Journal
Nature neuroscience
Author(s)
Valentinova K., Tchenio A., Trusel M., Clerke J.A., Lalive A.L., Tzanoulinou S., Matera A., Moutkine I., Maroteaux L., Paolicelli R.C., Volterra A., Bellone C., Mameli M.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
22
Number
7
Pages
1053-1056
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.
Keywords
Adaptation, Psychological, Animals, Cytokines/physiology, Female, Habenula/physiology, Male, Mice, Mice, Inbred C57BL, Microglia/physiology, Morphine/adverse effects, Naloxone/toxicity, Neuronal Plasticity, Random Allocation, Receptors, Glutamate/analysis, Receptors, N-Methyl-D-Aspartate/analysis, Receptors, Tumor Necrosis Factor, Type I/genetics, Receptors, Tumor Necrosis Factor, Type I/physiology, Social Behavior, Substance Withdrawal Syndrome/physiopathology, Substance Withdrawal Syndrome/psychology, Synaptic Transmission/physiology, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Create date
24/06/2019 17:41
Last modification date
03/10/2020 6:21
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