Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Valentinova, K.; Tchenio, A.; Trusel, M.; Clerke, J.A.; Lalive, A.L.; Tzanoulinou, S.; Matera, A.; Moutkine, I.; Maroteaux, L.; Paolicelli, R.C.; Volterra, A.; Bellone, C.; Mameli, M.

doi:10.1038/s41593-019-0421-4

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Details

Download: 31209376_cover.pdf (3059.44 [Ko])
State: Public
Version: Author's accepted manuscript
License: All rights reserved

Secondary document(s)

Download: 78956_3_supp_814321_pqr5ch.pdf (557.76 [Ko])
State: Public
Version: Supplementary document
License: CC BY 4.0

Serval ID

serval:BIB_42894FBE4719

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Journal

Nature neuroscience

Author(s)

Valentinova K., Tchenio A., Trusel M., Clerke J.A., Lalive A.L., Tzanoulinou S., Matera A., Moutkine I., Maroteaux L., Paolicelli R.C., Volterra A., Bellone C., Mameli M.

ISSN

1546-1726 (Electronic)

ISSN-L

1097-6256

Publication state

Published

Issued date

07/2019

Peer-reviewed

Oui

Volume

Number

Pages

1053-1056

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

Keywords

Adaptation, Psychological, Animals, Cytokines/physiology, Female, Habenula/physiology, Male, Mice, Mice, Inbred C57BL, Microglia/physiology, Morphine/adverse effects, Naloxone/toxicity, Neuronal Plasticity, Random Allocation, Receptors, Glutamate/analysis, Receptors, N-Methyl-D-Aspartate/analysis, Receptors, Tumor Necrosis Factor, Type I/genetics, Receptors, Tumor Necrosis Factor, Type I/physiology, Social Behavior, Substance Withdrawal Syndrome/physiopathology, Substance Withdrawal Syndrome/psychology, Synaptic Transmission/physiology, Tumor Necrosis Factor-alpha/physiology

URN

urn:nbn:ch:serval-BIB_42894FBE47195

OAI-PMH

oai:serval.unil.ch:BIB_42894FBE4719

DOI

10.1038/s41593-019-0421-4

Pubmed

31209376

Web of science

000472612100005

Create date

24/06/2019 16:41