Detection of erythropoiesis-stimulating agents in human anti-doping control: past, present and future.

Details

Serval ID
serval:BIB_4276B53027BB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Detection of erythropoiesis-stimulating agents in human anti-doping control: past, present and future.
Journal
Bioanalysis
Author(s)
Leuenberger N., Reichel C., Lasne F.
ISSN
1757-6199 (Electronic)
ISSN-L
1757-6180
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
4
Number
13
Pages
1565-1575
Language
english
Notes
Publication types: Journal Article WOS Document Type: Review
Abstract
Stimulation of erythropoiesis is one of the most efficient ways of doping. This type of doping is advantageous for aerobic physical exercise and of particular interest to endurance athletes. Erythropoiesis, which takes place in bone marrow, is under the control of EPO, a hormone secreted primarily by the kidneys when the arterial oxygen tension decreases. In certain pathological disorders, such as chronic renal failure, the production of EPO is insufficient and results in anemia. The pharmaceutical industry has, thus, been very interested in developing drugs that stimulate erythropoiesis. With this aim, various strategies have been, and continue to be, envisaged, giving rise to an expanding range of drugs that are good candidates for doping. Anti-doping control has had to deal with this situation by developing appropriate methods for their detection. This article presents an overview of both the drugs and the corresponding methods of detection, and thus follows a roughly chronological order.
Pubmed
Web of science
Create date
26/10/2012 18:30
Last modification date
20/08/2019 13:45
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