Detection of erythropoiesis-stimulating agents in human anti-doping control: past, present and future.

Détails

ID Serval
serval:BIB_4276B53027BB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Detection of erythropoiesis-stimulating agents in human anti-doping control: past, present and future.
Périodique
Bioanalysis
Auteur⸱e⸱s
Leuenberger N., Reichel C., Lasne F.
ISSN
1757-6199 (Electronic)
ISSN-L
1757-6180
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
4
Numéro
13
Pages
1565-1575
Langue
anglais
Notes
Publication types: Journal Article WOS Document Type: Review
Résumé
Stimulation of erythropoiesis is one of the most efficient ways of doping. This type of doping is advantageous for aerobic physical exercise and of particular interest to endurance athletes. Erythropoiesis, which takes place in bone marrow, is under the control of EPO, a hormone secreted primarily by the kidneys when the arterial oxygen tension decreases. In certain pathological disorders, such as chronic renal failure, the production of EPO is insufficient and results in anemia. The pharmaceutical industry has, thus, been very interested in developing drugs that stimulate erythropoiesis. With this aim, various strategies have been, and continue to be, envisaged, giving rise to an expanding range of drugs that are good candidates for doping. Anti-doping control has had to deal with this situation by developing appropriate methods for their detection. This article presents an overview of both the drugs and the corresponding methods of detection, and thus follows a roughly chronological order.
Pubmed
Web of science
Création de la notice
26/10/2012 18:30
Dernière modification de la notice
20/08/2019 13:45
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