Prevalence of anaemia in inflammatory bowel disease in Switzerland: a cross-sectional study in patients from private practices and university hospitals.
Details
Request a copy Under indefinite embargo.UNIL restricted access
State: Public
Version: author
Serval ID
serval:BIB_40EE2D5AF539
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of anaemia in inflammatory bowel disease in Switzerland: a cross-sectional study in patients from private practices and university hospitals.
Journal
Journal of Crohn's and Colitis
Working group(s)
Swiss IBD Cohort Study
Contributor(s)
Bauerfeind P., Begré S., Bengoa J., Binek J., Boller D., Borovicka J., Brägger C., Brun P., Burnand B., Camara R., Criblez D., de Saussure P., Degen L., Delarive J., Ehmann T., Engelmann M., El Wafa A., Felley C., Frei A., Frei R., Friedt M., Froehlich F., Gallot-Lavallée S., Gerlach T., Geyer M., Girardin M., Goetze O., Haack H., Hediger S., Hengstler P., Heyland K., Janiak P., Juillerat P., Brondolo VK., Knoblauch C., Kullak-Ublick GA., Manz M., Meier R., Meyenberger C., Michetti P., Mottet C., Müller C., Müllhaupt B., Nicolet T., Nydegger A., Pache I., Piccoli F., Pilz J., Rentsch R., Rey JP., Rogler D., Rihs S., Sagmeister M., Sauter B., Schaub N., Schibli S., Seibold F., Spalinger J., Stadler P., Steuerwald M., Sulz M., Tempia-Caliera M., Thorens£££Joël£££ J. , Vader JP., Von Känel R., Wachter G., Wermuth J., Wiesel P.
ISSN
1876-4479 (Electronic)
ISSN-L
1873-9946
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
4
Number
6
Pages
642-648
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
BACKGROUND: Anaemia represents a common complication of inflammatory bowel disease (IBD). Most studies on anaemia in IBD patients have been performed in tertiary referral centres (RC) and data from gastroenterologic practices (GP) are lacking. We investigated the frequency and severity of anaemia in IBD patients from tertiary referral centres and gastroenterologic practices compared to the general population.
METHODS: Data were acquired from patients included in the Swiss IBD Cohort Study. IBD activity was evaluated by CDAI and modified Truelove and Witts severity index (MTWSI). Anaemia was defined as haemoglobin ≤120g/L in women and ≤130g/L in men.
RESULTS: 125 patients from RC (66 with Crohn's disease (CD) and 59 with ulcerative colitis (UC)) and 116 patients from GP (71 CD and 45 UC) were included and compared to 6074 blood donors. Anaemia was found in 21.2% (51/241) of the IBD patients and more frequently in patients from RC as compared to GP and healthy controls (28.8% vs. 12.9% vs. 3.4%; P<0.01). IBD patients from RC suffered more frequently from active disease compared to IBD patients in GP (36% vs. 23%, P=0.032). Supplementation therapy (iron, vitamin B12, folic acid) was performed in 40% of anaemic IBD patients in GP as compared to 43% in RC.
CONCLUSIONS: Anaemia is a common complication in patients with IBD and significantly more prevalent in patients from referral centres as compared to patients from gastroenterologic practices. Physicians treating IBD patients should pay attention to the presence of anaemia and ensure sufficient supplementation therapy.
METHODS: Data were acquired from patients included in the Swiss IBD Cohort Study. IBD activity was evaluated by CDAI and modified Truelove and Witts severity index (MTWSI). Anaemia was defined as haemoglobin ≤120g/L in women and ≤130g/L in men.
RESULTS: 125 patients from RC (66 with Crohn's disease (CD) and 59 with ulcerative colitis (UC)) and 116 patients from GP (71 CD and 45 UC) were included and compared to 6074 blood donors. Anaemia was found in 21.2% (51/241) of the IBD patients and more frequently in patients from RC as compared to GP and healthy controls (28.8% vs. 12.9% vs. 3.4%; P<0.01). IBD patients from RC suffered more frequently from active disease compared to IBD patients in GP (36% vs. 23%, P=0.032). Supplementation therapy (iron, vitamin B12, folic acid) was performed in 40% of anaemic IBD patients in GP as compared to 43% in RC.
CONCLUSIONS: Anaemia is a common complication in patients with IBD and significantly more prevalent in patients from referral centres as compared to patients from gastroenterologic practices. Physicians treating IBD patients should pay attention to the presence of anaemia and ensure sufficient supplementation therapy.
Keywords
Adult, Anemia/blood, Anemia/drug therapy, Anemia, Iron-Deficiency/blood, Anemia, Iron-Deficiency/drug therapy, Colitis, Ulcerative/blood, Colitis, Ulcerative/complications, Crohn Disease/blood, Crohn Disease/complications, Cross-Sectional Studies, Dietary Supplements/statistics & numerical data, Erythrocyte Indices, Female, Ferritins/analysis, Folic Acid/therapeutic use, Hospitals, University/statistics & numerical data, Humans, Inflammatory Bowel Diseases/blood, Inflammatory Bowel Diseases/complications, Iron/therapeutic use, Male, Middle Aged, Prevalence, Private Practice/statistics & numerical data, Prospective Studies, Severity of Illness Index, Sex Distribution, Switzerland/epidemiology, Vitamin B 12/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
15/11/2010 9:58
Last modification date
20/08/2019 14:40
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