Crosstalk of T cells within the ovarian cancer microenvironment.

Details

Serval ID
serval:BIB_40EBC2F4EC7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Crosstalk of T cells within the ovarian cancer microenvironment.
Journal
Trends in cancer
Author(s)
Chap B.S., Rayroux N., Grimm A.J., Ghisoni E., Dangaj Laniti D.
ISSN
2405-8025 (Electronic)
ISSN-L
2405-8025
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Ovarian cancer (OC) represents ecosystems of highly diverse tumor microenvironments (TMEs). The presence of tumor-infiltrating lymphocytes (TILs) is linked to enhanced immune responses and long-term survival. In this review we present emerging evidence suggesting that cellular crosstalk tightly regulates the distribution of TILs within the TME, underscoring the need to better understand key cellular networks that promote or impede T cell infiltration in OC. We also capture the emergent methodologies and computational techniques that enable the dissection of cell-cell crosstalk. Finally, we present innovative ex vivo TME models that can be leveraged to map and perturb cellular communications to enhance T cell infiltration and immune reactivity.
Keywords
3D tumor models, T cell, cellular crosstalk, ovarian cancer, spatial omics, tumor microenvironment
Pubmed
Open Access
Yes
Create date
04/10/2024 15:12
Last modification date
05/10/2024 6:03
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