The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Details
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_3F87E3AD1020
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Journal
Nucleic acids research
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
02/11/2017
Peer-reviewed
Oui
Volume
45
Number
19
Pages
10941-10947
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1-5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention.
Keywords
Gene Expression Regulation, Humans, Mitochondrial Proteins/genetics, Mitochondrial Proteins/metabolism, Protein Serine-Threonine Kinases/genetics, Protein Serine-Threonine Kinases/metabolism, RNA/genetics, RNA/metabolism, RNA, Messenger/genetics, RNA, Messenger/metabolism, RNA, Mitochondrial, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism
Pubmed
Web of science
Publisher's website
Open Access
Yes
Create date
13/04/2021 16:25
Last modification date
21/11/2022 8:27
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