Article: article d'un périodique ou d'un magazine.
Etude de cas (case report): rapporte une observation et la commente brièvement.
Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.
Leukemia and Lymphoma
Date de publication
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.
Aged, Cells, Cultured, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cyclin D1/metabolism, Diagnosis, Differential, Female, Flow Cytometry, Humans, Immunoenzyme Techniques, Karyotyping, Lymphoma, Mantle-Cell/diagnosis, Lymphoma, Mantle-Cell/metabolism, Prognosis, Splenic Neoplasms/diagnosis, Splenic Neoplasms/metabolism, Translocation, Genetic
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