Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.

Détails

ID Serval
serval:BIB_3DF62E0CC0E1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.
Périodique
Leukemia and Lymphoma
Auteur⸱e⸱s
Björck E., Landgren O., Schoumans J., Christensson B., Björkholm M., MacDonald A.P., Nordenskjöld M.
ISSN
1042-8194 (Print)
ISSN-L
1026-8022
Statut éditorial
Publié
Date de publication
2003
Volume
44
Numéro
7
Pages
1229-1234
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.
Mots-clé
Aged, Cells, Cultured, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cyclin D1/metabolism, Diagnosis, Differential, Female, Flow Cytometry, Humans, Immunoenzyme Techniques, Karyotyping, Lymphoma, Mantle-Cell/diagnosis, Lymphoma, Mantle-Cell/metabolism, Prognosis, Splenic Neoplasms/diagnosis, Splenic Neoplasms/metabolism, Translocation, Genetic
Pubmed
Web of science
Création de la notice
17/09/2011 9:55
Dernière modification de la notice
20/08/2019 13:34
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