Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.
Details
Serval ID
serval:BIB_3DF62E0CC0E1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.
Journal
Leukemia and Lymphoma
ISSN
1042-8194 (Print)
ISSN-L
1026-8022
Publication state
Published
Issued date
2003
Volume
44
Number
7
Pages
1229-1234
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.
Keywords
Aged, Cells, Cultured, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cyclin D1/metabolism, Diagnosis, Differential, Female, Flow Cytometry, Humans, Immunoenzyme Techniques, Karyotyping, Lymphoma, Mantle-Cell/diagnosis, Lymphoma, Mantle-Cell/metabolism, Prognosis, Splenic Neoplasms/diagnosis, Splenic Neoplasms/metabolism, Translocation, Genetic
Pubmed
Web of science
Create date
17/09/2011 10:55
Last modification date
20/08/2019 14:34
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