Neurological adverse events associated with cancer immunotherapies: literature review and database development

Details

Ressource 1 Under indefinite embargo.
UNIL restricted access
State: Public
Version: After imprimatur
License: Not specified
Secondary document(s)
Under indefinite embargo.
UNIL restricted access
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_3DC9613DC448
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
Neurological adverse events associated with cancer immunotherapies: literature review and database development
Author(s)
DESBAILLETS N.
Director(s)
HOTTINGER A.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2020
Language
english
Number of pages
36
Abstract
In oncology, immunotherapeutic approaches have revolutionized the management of many cancer types. These treatments, although very effective, are associated with immune adverse events that are new and poorly known, including neurological adverse events. These side effects, if not recognized and treated early, present not only a risk to neurological function, but also to the oncological prognosis. This master's thesis briefly explains the different immunotherapeutic approaches used in oncology before presenting a systematic review of the literature identifying the neurological adverse events known to date in both the central and peripheral nervous systems. Management recommendations for each adverse event are also discussed. Finally, the architecture and functioning of a database allowing prospective capturing of patients with neurological complications related to immune oncology treatments are discussed.
Keywords
Immunotherapies, Cancer, Adverse Event, Neurologic
Create date
09/09/2021 9:56
Last modification date
04/10/2022 6:38
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