Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages
Details
Serval ID
serval:BIB_3CFAA62FAAC0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages
Journal
Neuromuscular Disorders
ISSN
0960-8966 (Print)
Publication state
Published
Issued date
07/2006
Peer-reviewed
Oui
Volume
16
Number
7
Pages
468-471
Language
english
Notes
Case Reports Journal Article --- Old month value: Jul
Abstract
Dermatomyositis (DM) is a rare treatable muscle disorder with a reported favorable outcome in most patients. A localized skin/muscle involvement in a DM patient raises questions of definition and causes such as lymphoma, or relapse. We describe here a young treated DM patient who presented a focal biopsy-proven destructive myositis and dermatitis restricted to the left thigh 15 months after the onset of a treated dermatomyositis. There was evidence of subcutaneous lobular panniculitis, somewhat resembling cytophagic histocytic panniculitis associated with a focal inflammatory myopathy with abundant macrophages that destroyed the sartorius muscle. Mild signs of hemophagocytosis and T-CD3 lymphocytosis were present in the bone marrow, but no monoclonal T-lymphocyte expansion was observed, as searched by autoradiography of the totality of TcR Vgamma families. The patient improved with prednisone and azathioprine. We conclude that this focal complication suggests a continuum between dermatomyositis, CHP, and IMAM, the three syndromes where T-cell activation plays an important role.
Keywords
Adult Biopsy Dermatomyositis/immunology/*pathology Humans Macrophages/*pathology Magnetic Resonance Imaging Male Muscle, Skeletal/pathology Myositis/immunology/*pathology Panniculitis/immunology/*pathology
Pubmed
Web of science
Create date
25/01/2008 16:31
Last modification date
20/08/2019 14:33