Article: article from journal or magazin.
Influences of body weight, body composition, and substrate oxidation rate on resting postabsorptive glucose production and gluconeogenesis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
OBJECTIVE: To determine the influence of body weight, fat mass, and fat distribution on resting endogenous glucose production in healthy lean and overweight individuals. DESIGN: measurements were performed in the resting postabsorptive state in individuals receiving an unrestricted diet. SETTING: Institute of Physiology of Lausanne University. MEASUREMENTS: resting post absorptive glucose production, glycogenolysis and gluconeogenesis; resting energy expenditure and net substrate oxidation. RESULTS: Endogenous glucose production was positively correlated with body weight, lean body mass, energy expenditure and carbohydrate oxidation. Gluconeogenesis was positively correlated with net lipid oxidation and energy expenditure, and negatively correlated with net carbohydrate oxidation. No correlation with body fat or fat distribution was observed. CONCLUSIONS: Gluconeogenesis shows a large interindividual variability. Net lipid oxidation and not body fat appears to be a major determinant of gluconeogenesis.
Adult, Body Composition, Body Mass Index, Body Weight, Carbohydrate Metabolism, Energy Metabolism, Female, Gluconeogenesis, Glucose, Glycogen, Humans, Kinetics, Lipid Metabolism, Male, Oxidation-Reduction
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