Influences of body weight, body composition, and substrate oxidation rate on resting postabsorptive glucose production and gluconeogenesis.

Détails

ID Serval
serval:BIB_3CBF8381E544
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Influences of body weight, body composition, and substrate oxidation rate on resting postabsorptive glucose production and gluconeogenesis.
Périodique
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Auteur(s)
Giusti V., Schneiter P., Thiébaud D., Landry M., Burckhardt P., Jéquier E., Tappy L.
ISSN
0307-0565
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
20
Numéro
9
Pages
842-7
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: To determine the influence of body weight, fat mass, and fat distribution on resting endogenous glucose production in healthy lean and overweight individuals. DESIGN: measurements were performed in the resting postabsorptive state in individuals receiving an unrestricted diet. SETTING: Institute of Physiology of Lausanne University. MEASUREMENTS: resting post absorptive glucose production, glycogenolysis and gluconeogenesis; resting energy expenditure and net substrate oxidation. RESULTS: Endogenous glucose production was positively correlated with body weight, lean body mass, energy expenditure and carbohydrate oxidation. Gluconeogenesis was positively correlated with net lipid oxidation and energy expenditure, and negatively correlated with net carbohydrate oxidation. No correlation with body fat or fat distribution was observed. CONCLUSIONS: Gluconeogenesis shows a large interindividual variability. Net lipid oxidation and not body fat appears to be a major determinant of gluconeogenesis.
Mots-clé
Adult, Body Composition, Body Mass Index, Body Weight, Carbohydrate Metabolism, Energy Metabolism, Female, Gluconeogenesis, Glucose, Glycogen, Humans, Kinetics, Lipid Metabolism, Male, Oxidation-Reduction
Pubmed
Web of science
Création de la notice
24/01/2008 13:36
Dernière modification de la notice
20/08/2019 13:32
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