Article: article from journal or magazin.
Reassessment of recommended imipenem doses in febrile neutropenic patients with hematological malignancies.
Antimicrobial Agents and Chemotherapy
Imipenem plasma concentrations were analyzed in 57 febrile neutropenic patients using the NONMEM program. The recommended 2-g/day regimen achieved coverage of the most common bacteria (MIC(90) = 1 mg/liter) during the whole dosing interval in only 53% of patients. This goal was achieved in 90% of patients with 3 g/day.
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