Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.
Details
Serval ID
serval:BIB_3C51E6BA58FF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.
Journal
Cells
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Publication state
Published
Issued date
30/11/2021
Peer-reviewed
Oui
Volume
10
Number
12
Pages
3368
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Parkinson's disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson's disease. Our previous findings of a higher survival of dopaminergic neurons in the substantia nigra co-expressing Nogo-A in an animal model of Parkinson's disease suggested that Nogo-A may be associated with dopaminergic neurons resilience against Parkinson's disease neurodegeneration. In the present study, we have addressed the expression of Nogo-A in the dopaminergic neurons in the substantia nigra in postmortem specimens of diseased and non-diseased subjects of different ages. For this purpose, in a collaborative effort we developed a tissue micro array (TMA) that allows for simultaneous staining of many samples in a single run. Interestingly, and in contrast to the observations gathered during normal aging and in the animal model of Parkinson's disease, increasing age was significantly associated with a lower co-expression of Nogo-A in nigral dopaminergic neurons of patients with Parkinson's disease. In sum, while Nogo-A expression in dopaminergic neurons is higher with increasing age, the opposite is the case in Parkinson's disease. These observations suggest that Nogo-A might play a substantial role in the vulnerability of dopaminergic neurons in Parkinson's disease.
Keywords
Age Factors, Aged, Aged, 80 and over, Aging/metabolism, Cell Count, Dopaminergic Neurons/metabolism, Humans, Male, Nogo Proteins/metabolism, Parkinson Disease/metabolism, Substantia Nigra/metabolism, Tyrosine 3-Monooxygenase/metabolism, Nogo-A, Parkinson’s disease, human, immunofluorescence, substantia nigra pars compacta, tyrosine hydroxylase
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2022 8:57
Last modification date
22/07/2022 6:09