Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.

Détails

Ressource 1Télécharger: 34943877.pdf (4775.39 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_3C51E6BA58FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.
Périodique
Cells
Auteur⸱e⸱s
Eyer G.C., Di Santo S., Hewer E., Andereggen L., Seiler S., Widmer H.R.
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Statut éditorial
Publié
Date de publication
30/11/2021
Peer-reviewed
Oui
Volume
10
Numéro
12
Pages
3368
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Parkinson's disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson's disease. Our previous findings of a higher survival of dopaminergic neurons in the substantia nigra co-expressing Nogo-A in an animal model of Parkinson's disease suggested that Nogo-A may be associated with dopaminergic neurons resilience against Parkinson's disease neurodegeneration. In the present study, we have addressed the expression of Nogo-A in the dopaminergic neurons in the substantia nigra in postmortem specimens of diseased and non-diseased subjects of different ages. For this purpose, in a collaborative effort we developed a tissue micro array (TMA) that allows for simultaneous staining of many samples in a single run. Interestingly, and in contrast to the observations gathered during normal aging and in the animal model of Parkinson's disease, increasing age was significantly associated with a lower co-expression of Nogo-A in nigral dopaminergic neurons of patients with Parkinson's disease. In sum, while Nogo-A expression in dopaminergic neurons is higher with increasing age, the opposite is the case in Parkinson's disease. These observations suggest that Nogo-A might play a substantial role in the vulnerability of dopaminergic neurons in Parkinson's disease.
Mots-clé
Age Factors, Aged, Aged, 80 and over, Aging/metabolism, Cell Count, Dopaminergic Neurons/metabolism, Humans, Male, Nogo Proteins/metabolism, Parkinson Disease/metabolism, Substantia Nigra/metabolism, Tyrosine 3-Monooxygenase/metabolism, Nogo-A, Parkinson’s disease, human, immunofluorescence, substantia nigra pars compacta, tyrosine hydroxylase
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/01/2022 8:57
Dernière modification de la notice
22/07/2022 6:09
Données d'usage