Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy.

Details

Serval ID
serval:BIB_3A5FCD94382F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy.
Journal
Oral oncology
Author(s)
Evrard D., Szturz P., Tijeras-Raballand A., Astorgues-Xerri L., Abitbol C., Paradis V., Raymond E., Albert S., Barry B., Faivre S.
ISSN
1879-0593 (Electronic)
ISSN-L
1368-8375
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
88
Pages
29-38
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The microenvironment of solid tumors has become a promising target for future therapies modulating immune cells. Patients with advanced head and neck cancer, which still portends a poor outcome, are particularly in need of innovative approaches. In oral squamous cell carcinoma, high density of tumor-associated macrophages (TAMs) appears consistently associated with poor prognosis, whereas data are currently limited for other head and neck sites. Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype. This review focuses on both prognostic and therapeutic aspects related to TAMs in head and neck carcinomas.
Keywords
Antineoplastic Agents/pharmacology, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/immunology, Head and Neck Neoplasms/virology, Humans, Immunomodulation, Macrophage Activation/drug effects, Macrophage Colony-Stimulating Factor/antagonists & inhibitors, Macrophages/classification, Macrophages/drug effects, Macrophages/immunology, Macrophages/metabolism, Molecular Targeted Therapy/methods, Prognosis, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors, Tumor Microenvironment/immunology, CSF-1R inhibitor, Cancer treatment, Protumoral activities, Targeted therapy, Tumor microenvironment, Tumor-associated macrophages (TAMs)
Pubmed
Web of science
Create date
20/01/2019 16:23
Last modification date
06/12/2020 7:26
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