Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy.

Détails

ID Serval
serval:BIB_3A5FCD94382F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy.
Périodique
Oral oncology
Auteur(s)
Evrard D., Szturz P., Tijeras-Raballand A., Astorgues-Xerri L., Abitbol C., Paradis V., Raymond E., Albert S., Barry B., Faivre S.
ISSN
1879-0593 (Electronic)
ISSN-L
1368-8375
Statut éditorial
Publié
Date de publication
01/2019
Peer-reviewed
Oui
Volume
88
Pages
29-38
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The microenvironment of solid tumors has become a promising target for future therapies modulating immune cells. Patients with advanced head and neck cancer, which still portends a poor outcome, are particularly in need of innovative approaches. In oral squamous cell carcinoma, high density of tumor-associated macrophages (TAMs) appears consistently associated with poor prognosis, whereas data are currently limited for other head and neck sites. Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype. This review focuses on both prognostic and therapeutic aspects related to TAMs in head and neck carcinomas.
Mots-clé
Antineoplastic Agents/pharmacology, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/immunology, Head and Neck Neoplasms/virology, Humans, Immunomodulation, Macrophage Activation/drug effects, Macrophage Colony-Stimulating Factor/antagonists & inhibitors, Macrophages/classification, Macrophages/drug effects, Macrophages/immunology, Macrophages/metabolism, Molecular Targeted Therapy/methods, Prognosis, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors, Tumor Microenvironment/immunology, CSF-1R inhibitor, Cancer treatment, Protumoral activities, Targeted therapy, Tumor microenvironment, Tumor-associated macrophages (TAMs)
Pubmed
Web of science
Création de la notice
20/01/2019 16:23
Dernière modification de la notice
06/12/2020 7:26
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