LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.

Details

Serval ID
serval:BIB_3A41038D401E
Type
Article: article from journal or magazin.
Collection
Publications
Title
LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
Journal
Parkinsonism and Related Disorders
Author(s)
Vilariño-Güell C., Ross O.A., Wider C., Jasinska-Myga B., Cobb S.A., Soto-Ortolaza A.I., Kachergus J.M., Keeling B.H., Dachsel J.C., Melrose H.L., Behrouz B., Wszolek Z.K., Uitti R.J., Aasly J.O., Rajput A., Farrer M.J.
ISSN
1873-5126[electronic], 1353-8020[linking]
Publication state
Published
Issued date
2010
Volume
16
Number
2
Pages
109-111
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Abstract
Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
Keywords
Adult, Aged, Aged, 80 and over, Case-Control Studies, Essential Tremor/genetics, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Membrane Proteins/genetics, Middle Aged, Nerve Tissue Proteins/genetics, Parkinson Disease/genetics, Polymorphism, Genetic/genetics
Pubmed
Create date
24/09/2010 18:01
Last modification date
20/08/2019 13:29
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