LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.

Détails

ID Serval
serval:BIB_3A41038D401E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
Périodique
Parkinsonism and Related Disorders
Auteur⸱e⸱s
Vilariño-Güell C., Ross O.A., Wider C., Jasinska-Myga B., Cobb S.A., Soto-Ortolaza A.I., Kachergus J.M., Keeling B.H., Dachsel J.C., Melrose H.L., Behrouz B., Wszolek Z.K., Uitti R.J., Aasly J.O., Rajput A., Farrer M.J.
ISSN
1873-5126[electronic], 1353-8020[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
16
Numéro
2
Pages
109-111
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Résumé
Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
Mots-clé
Adult, Aged, Aged, 80 and over, Case-Control Studies, Essential Tremor/genetics, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Membrane Proteins/genetics, Middle Aged, Nerve Tissue Proteins/genetics, Parkinson Disease/genetics, Polymorphism, Genetic/genetics
Pubmed
Création de la notice
24/09/2010 18:01
Dernière modification de la notice
20/08/2019 13:29
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