Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer.
Details
Serval ID
serval:BIB_398A75EC540B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer.
Journal
Frontiers in oncology
Working group(s)
REACCT Collaborative
Contributor(s)
Zaborowski A.M., Abdile A., Adamina M., Aigner F., d'Allens L., Allmer C., Álvarez A., Anula R., Andric M., Bach SAS, Bala M., Barussaud M., Bausys A., Beggs A., Bellolio F., Bennett M.R., Bevan V., Biondo S., Bislenghi G., Bludau M., Brown C., Bruns C., Buchanan D.D., Buchwald P., Burger J.W., Burlov N., Campanelli M., Capdepont M., Carvello M., Chew H.H., Christoforidis D., Clark D., Climent M., Collinson R., Cologne K.G., Contreras T., Croner R., Daniels I.R., Dapri G., Davies J., Delrio P., Denost Q., Deutsch M., Dias A., D'Hoore A., Drozdov E., Duek D., Dunlop M., Dziki A., Edmundson A., Efetov S., El-Hussuna A., Elliott B., Emile S., Espin-Basany E., Evans M., Faes S., Faiz O., Figueiredo N., Fleming F., Foppa C., Fowler G., Frasson M., Forgan T., Frizelle F., Gadaev S., Gellona J., Glyn T., Goran B., Greenwood E., Guren M.G., Guillon S., Gutlic I., Hahnloser D., Hampel H., Hanly A., Hasegawa H., Iversen L.H., Hill A., Hill J., Hoch J., Hompes R., Hurtado L., Iaquinandi F., Imbrasaite U., Islam R., Jafari M.D., Salido A.J., Jiménez-Toscano M., Kanemitsu Y., Karachun A., Karimuddin A.A., Keller D.S., Kelly J., Kennelly R., Khrykov G., Kocian P., Koh C., Kok N., Knight K.A., Knol J., Kontovounisios C., Korner H., Krivokapic Z., Kronberger I., Kroon H.M., Kryzauskas M., Kural S., Kusters M., Lakkis Z., Lankov T., Larson D., Lázár G., Lee K.Y., Lee S.H., Lefèvre J.H., Lepisto A., Lieu C., Loi L., Lynch C., Maillou-Martinaud H., Maroli A., Martin S.T., Martling A., Matzel K.E., Mayol J., McDermott F., Meurette G., Millan M., Mitteregger M., Moiseenko A., Monson J.R., Morarasu S., Moritani K., Möslein G., Munini M., Nahas C., Nahas S., Negoi I., Novikova A., Ocares M., Okabayashi K., Olkina A., Oñate-Ocaña L., Otero J., Ozen C., Pace U., Julião GPS, Panaiotti L., Panis Y., Papamichael D., Patel S., Uriburu JCP, Peng S.L., Pera M., Perez R.O., Petrov A., Pfeffer F., Phang T.P., Poskus T., Pringle H., Proud D., Raguz I., Rama N., Rasheed S., Raval M.J., Rega D., Reissfelder C., Meneses JCR, Ris F., Riss S., Rodriguez-Zentner H., Roxburgh C.S., Saklani A., Sammour T., Saraste D., Schneider M., Seishima R., Sekulic A., Seppala T., Sheahan K., Shlomina A., Sica G., Singnomklao T., Siragusa L., Smart N., Solis-Peña A., Spinelli A., Staiger R.D., Stamos M.J., Steele S., Tan K.K., Tanis P.J., Tekkis P., Teklay B., Tengku S., Tsarkov P., Turina M., Ulrich A., Vailati B.B., van Harten M., Verhoef C., Warrier S., Wexner S., Weinberg B.A., Wells C., Wolthuis A., Xynos E., You N., Zakharenko A., Zeballos J., Zhou Y., Winter D.C.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
12
Pages
868359
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (<50 years) is rising, there is little data on functional outcomes in this group.
The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes.
A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%).
A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes.
A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%).
A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
Keywords
early onset rectal cancer, functional outcome, patient reported outcome (PROM), rectal cancer, young rectal cancer
Pubmed
Web of science
Open Access
Yes
Create date
26/09/2023 15:23
Last modification date
16/02/2024 8:58
Usage data
