Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_398A75EC540B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer.
Périodique
Frontiers in oncology
Collaborateur⸱rice⸱s
REACCT Collaborative
Contributeur⸱rice⸱s
Zaborowski A.M., Abdile A., Adamina M., Aigner F., d'Allens L., Allmer C., Álvarez A., Anula R., Andric M., Bach SAS, Bala M., Barussaud M., Bausys A., Beggs A., Bellolio F., Bennett M.R., Bevan V., Biondo S., Bislenghi G., Bludau M., Brown C., Bruns C., Buchanan D.D., Buchwald P., Burger J.W., Burlov N., Campanelli M., Capdepont M., Carvello M., Chew H.H., Christoforidis D., Clark D., Climent M., Collinson R., Cologne K.G., Contreras T., Croner R., Daniels I.R., Dapri G., Davies J., Delrio P., Denost Q., Deutsch M., Dias A., D'Hoore A., Drozdov E., Duek D., Dunlop M., Dziki A., Edmundson A., Efetov S., El-Hussuna A., Elliott B., Emile S., Espin-Basany E., Evans M., Faes S., Faiz O., Figueiredo N., Fleming F., Foppa C., Fowler G., Frasson M., Forgan T., Frizelle F., Gadaev S., Gellona J., Glyn T., Goran B., Greenwood E., Guren M.G., Guillon S., Gutlic I., Hahnloser D., Hampel H., Hanly A., Hasegawa H., Iversen L.H., Hill A., Hill J., Hoch J., Hompes R., Hurtado L., Iaquinandi F., Imbrasaite U., Islam R., Jafari M.D., Salido A.J., Jiménez-Toscano M., Kanemitsu Y., Karachun A., Karimuddin A.A., Keller D.S., Kelly J., Kennelly R., Khrykov G., Kocian P., Koh C., Kok N., Knight K.A., Knol J., Kontovounisios C., Korner H., Krivokapic Z., Kronberger I., Kroon H.M., Kryzauskas M., Kural S., Kusters M., Lakkis Z., Lankov T., Larson D., Lázár G., Lee K.Y., Lee S.H., Lefèvre J.H., Lepisto A., Lieu C., Loi L., Lynch C., Maillou-Martinaud H., Maroli A., Martin S.T., Martling A., Matzel K.E., Mayol J., McDermott F., Meurette G., Millan M., Mitteregger M., Moiseenko A., Monson J.R., Morarasu S., Moritani K., Möslein G., Munini M., Nahas C., Nahas S., Negoi I., Novikova A., Ocares M., Okabayashi K., Olkina A., Oñate-Ocaña L., Otero J., Ozen C., Pace U., Julião GPS, Panaiotti L., Panis Y., Papamichael D., Patel S., Uriburu JCP, Peng S.L., Pera M., Perez R.O., Petrov A., Pfeffer F., Phang T.P., Poskus T., Pringle H., Proud D., Raguz I., Rama N., Rasheed S., Raval M.J., Rega D., Reissfelder C., Meneses JCR, Ris F., Riss S., Rodriguez-Zentner H., Roxburgh C.S., Saklani A., Sammour T., Saraste D., Schneider M., Seishima R., Sekulic A., Seppala T., Sheahan K., Shlomina A., Sica G., Singnomklao T., Siragusa L., Smart N., Solis-Peña A., Spinelli A., Staiger R.D., Stamos M.J., Steele S., Tan K.K., Tanis P.J., Tekkis P., Teklay B., Tengku S., Tsarkov P., Turina M., Ulrich A., Vailati B.B., van Harten M., Verhoef C., Warrier S., Wexner S., Weinberg B.A., Wells C., Wolthuis A., Xynos E., You N., Zakharenko A., Zeballos J., Zhou Y., Winter D.C.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Statut éditorial
Publié
Date de publication
2022
Peer-reviewed
Oui
Volume
12
Pages
868359
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (<50 years) is rising, there is little data on functional outcomes in this group.
The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes.
A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%).
A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes.
A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%).
A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters.
Mots-clé
early onset rectal cancer, functional outcome, patient reported outcome (PROM), rectal cancer, young rectal cancer
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/09/2023 14:23
Dernière modification de la notice
16/02/2024 7:58
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