Presence of peripheral blasts in refractory anemia and refractory cytopenia with multilineage dysplasia predicts an unfavourable outcome
Details
Serval ID
serval:BIB_391FDDCFFD30
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Presence of peripheral blasts in refractory anemia and refractory cytopenia with multilineage dysplasia predicts an unfavourable outcome
Journal
Leukemia Research
ISSN
0145-2126
Publication state
Published
Issued date
2008
Volume
32
Number
1
Pages
33-37
Language
english
Abstract
The World Health Organization (WHO) assigns myelodysplastic syndrome (MDS) to RA/RCMD/RARS/RSCM/5q- syndrome, if medullary blasts are <5% and peripheral blast (PB) count < or =1%. In 1103 patients with these diagnoses, we analysed survival and risk of AML evolution depending on the presence of PB. Median survival in the group with 1% PB (n=74) was significantly lower as compared to those without PB (20 versus 47 months, p<0.00005). Cumulative risk of AML was significantly higher in patients showing PB (p<0.00005). Median survival of patients with PB was not different from that of RAEB I. We therefore propose to consider patients with PB, regardless of medullary blast, as RAEB I.
Keywords
Adolescent, Adult, Aged, Aged,80 and over, Anemia, Anemia,Refractory, Anemia,Refractory,with Excess of Blasts, Anemia,Sideroblastic, Chromosome Aberrations, Female, genetics, Humans, Male, Middle Aged, mortality, Myelodysplastic Syndromes, Pancytopenia, pathology, Patients, Prognosis, Risk, Survival, Survival Rate, Switzerland, Syndrome, World Health
Pubmed
Create date
29/01/2009 22:13
Last modification date
31/10/2023 7:11
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