Presence of peripheral blasts in refractory anemia and refractory cytopenia with multilineage dysplasia predicts an unfavourable outcome
Détails
ID Serval
serval:BIB_391FDDCFFD30
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Presence of peripheral blasts in refractory anemia and refractory cytopenia with multilineage dysplasia predicts an unfavourable outcome
Périodique
Leukemia Research
ISSN
0145-2126
Statut éditorial
Publié
Date de publication
2008
Volume
32
Numéro
1
Pages
33-37
Langue
anglais
Résumé
The World Health Organization (WHO) assigns myelodysplastic syndrome (MDS) to RA/RCMD/RARS/RSCM/5q- syndrome, if medullary blasts are <5% and peripheral blast (PB) count < or =1%. In 1103 patients with these diagnoses, we analysed survival and risk of AML evolution depending on the presence of PB. Median survival in the group with 1% PB (n=74) was significantly lower as compared to those without PB (20 versus 47 months, p<0.00005). Cumulative risk of AML was significantly higher in patients showing PB (p<0.00005). Median survival of patients with PB was not different from that of RAEB I. We therefore propose to consider patients with PB, regardless of medullary blast, as RAEB I.
Mots-clé
Adolescent, Adult, Aged, Aged,80 and over, Anemia, Anemia,Refractory, Anemia,Refractory,with Excess of Blasts, Anemia,Sideroblastic, Chromosome Aberrations, Female, genetics, Humans, Male, Middle Aged, mortality, Myelodysplastic Syndromes, Pancytopenia, pathology, Patients, Prognosis, Risk, Survival, Survival Rate, Switzerland, Syndrome, World Health
Pubmed
Création de la notice
29/01/2009 23:13
Dernière modification de la notice
31/10/2023 8:11
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