Outlook: Roles of FSH and LH during the follicular phase: insight into natural cycle IVF

Details

Serval ID
serval:BIB_38C3DA5DE0D1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Outlook: Roles of FSH and LH during the follicular phase: insight into natural cycle IVF
Journal
Reproductive Biomedicine Online
Author(s)
de Ziegler  D., Fraisse  T., de Candolle  G., Vulliemoz  N., Bellavia  M., Colamaria  S.
ISSN
1472-6483
Publication state
Published
Issued date
11/2007
Peer-reviewed
Oui
Volume
15
Number
5
Pages
507-13
Notes
Journal Article
Review --- Old month value: Nov
Abstract
A mounting interest in natural cycle IVF has challenged the medical community to better understand the mechanisms controlling the follicular phase and ovulation in particular, in an effort to optimize this procedure and its outcome. For practical reasons, the advancement of the follicular phase in the menstrual cycle is commonly timed according to the onset of last menses. However, this precludes knowing when the follicular phase truly begins and hampers the possibility of optimizing timing of late follicular-phase events, notably, the triggering of ovulation. Clinicians, therefore, use surrogate markers of follicular maturation, such as oestrogen production and follicular size. Because it is impossible to identify the low-amplitude intercycle basal FSH signal, efforts have reverted toward controlling when it takes place, either with exogenous oestrogen or with oral contraceptives. In the late follicular phase, the occurrence of LH surge results from a balance between the opposite effects of rising oestrogen concentrations, which favour the LH surge, and the opposing effects mediated by the gonadotrophin surge-attenuating factor, a peptide of ovarian origin. This review looks into the mechanisms that control these two hinges of the follicular phase, the basal FSH signal and LH surge, in the context of optimizing natural cycle IVF.
Keywords
Contraceptives, Oral/therapeutic use Estrogens/physiology/therapeutic use Female Fertilization in Vitro/*methods Follicle Stimulating Hormone/*physiology Follicular Phase/*physiology Gonadal Hormones/physiology Humans Infertility, Female/drug therapy Luteinizing Hormone/*physiology Ovarian Follicle/*physiology Proteins/physiology
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2008 11:37
Last modification date
07/10/2019 8:12
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