MAR-Mediated Dystrophin Expression in Mesoangioblasts for Duchenne Muscular Dystrophy Cell Therapy

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_37D3FB4E9965
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MAR-Mediated Dystrophin Expression in Mesoangioblasts for Duchenne Muscular Dystrophy Cell Therapy
Périodique
Molecular Biology
Auteur(s)
van Zwieten R.W., Iyer P., Majocchi S., Dusserre Y., Puttini S., Tedesco F.S., Cossu G, Mermod N.
ISSN
2168-9547
Statut éditorial
Publié
Date de publication
2015
Volume
04
Numéro
03
Pages
134
Langue
anglais
Résumé
A cornerstone of autologous cell therapy for Duchenne muscular dystrophy is the engineering of suitable cells to express dystrophin in a stable fashion upon differentiation to muscle fibers. Most viral transduction methods are typically restricted to the expression of truncated recombinant dystrophin derivatives and by the risk of insertional mutagenesis, while non-viral vectors often suffer from inefficient transfer, expression and/or silencing.
Open Access
Oui
Création de la notice
31/01/2017 11:09
Dernière modification de la notice
20/08/2019 13:26
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