Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

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Serval ID
serval:BIB_37A31F8ED2F6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
Journal
Plos One
Author(s)
Coutu S., Rossi L., Barry D.A., Rudaz S., Vernaz N.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2013
Volume
8
Number
1
Pages
e53592
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.
Keywords
Anti-Bacterial Agents/analysis, Anti-Bacterial Agents/therapeutic use, Conservation of Natural Resources, Hospitals, Humans, Medical Waste/analysis, Models, Theoretical, Seasons, Switzerland, Waste Water/analysis, Water Pollutants, Chemical/analysis, Weather
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2013 20:26
Last modification date
20/08/2019 13:26
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