Comparison of Spinal Cord Stimulation vs. Dorsal Root Ganglion Stimulation vs. Association of Both in Patients with Refractory Chronic Back and/or Lower Limb Neuropathic Pain: An International, Prospective, Randomized, Double-Blinded, Crossover Trial (BOOST-DRG Study).

Details

Serval ID
serval:BIB_33CB1835D8B9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Comparison of Spinal Cord Stimulation vs. Dorsal Root Ganglion Stimulation vs. Association of Both in Patients with Refractory Chronic Back and/or Lower Limb Neuropathic Pain: An International, Prospective, Randomized, Double-Blinded, Crossover Trial (BOOST-DRG Study).
Journal
Medicina
Author(s)
Rigoard P., Roulaud M., Goudman L., Adjali N., Ounajim A., Voirin J., Perruchoud C., Bouche B., Page P., Guillevin R., Naudin M., Simoneau M., Lorgeoux B., Baron S., Nivole K., Many M., Maitre I., Rigoard R., David R., Moens M., Billot M.
ISSN
1648-9144 (Electronic)
ISSN-L
1010-660X
Publication state
Published
Issued date
21/12/2021
Peer-reviewed
Oui
Volume
58
Number
1
Pages
7
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Abstract
While spinal cord stimulation (SCS) is a well-established therapy to address refractory persistent spinal pain syndrome after spinal surgery (PSPS-T2), its lack of spatial selectivity and reported discomfort due to positional effects can be considered as significant limitations. As alternatives, new waveforms, such as burst stimulation and different spatial neural targets, such as dorsal root ganglion stimulation (DRGS), have shown promising results. Comparisons between DRGS and standard SCS, or their combination, have never been studied on the same patients. "BOOST DRG" is the first prospective, randomized, double-blinded, crossover study to compare SCS vs. DRGS vs. SCS+DRGS. Sixty-six PSPS-T2 patients will be recruited internationally in three centers. Before crossing over, patients will receive each stimulation modality for 1 month, using tonic conventional stimulation. After 3 months, stimulation will consist in switching to burst for 1 month, and patients will choose which modality/waveform they receive and will then be reassessed at 6 and 12 months. In addition to our primary outcome based on pain rating, this study is designed to assess quality of life, functional disability, psychological distress, pain surface coverage, global impression of change, medication quantification, adverse events, brain functional imaging and electroencephalography, with the objective being to provide a multidimensional insight based on composite pain assessment.
Keywords
Cross-Over Studies, Ganglia, Spinal, Humans, Lower Extremity, Neuralgia/therapy, Prospective Studies, Quality of Life, Spinal Cord Stimulation, burst, energy consumption, failed back surgery syndrome, hybrid stimulation, leg pain, neurostimulation, refractory pain
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2022 12:35
Last modification date
06/02/2024 8:18
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