Comparison of Spinal Cord Stimulation vs. Dorsal Root Ganglion Stimulation vs. Association of Both in Patients with Refractory Chronic Back and/or Lower Limb Neuropathic Pain: An International, Prospective, Randomized, Double-Blinded, Crossover Trial (BOOST-DRG Study).
Détails
Télécharger: 35056316_BIB_33CB1835D8B9.pdf (1712.16 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_33CB1835D8B9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Comparison of Spinal Cord Stimulation vs. Dorsal Root Ganglion Stimulation vs. Association of Both in Patients with Refractory Chronic Back and/or Lower Limb Neuropathic Pain: An International, Prospective, Randomized, Double-Blinded, Crossover Trial (BOOST-DRG Study).
Périodique
Medicina
ISSN
1648-9144 (Electronic)
ISSN-L
1010-660X
Statut éditorial
Publié
Date de publication
21/12/2021
Peer-reviewed
Oui
Volume
58
Numéro
1
Pages
7
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Publication Status: epublish
Résumé
While spinal cord stimulation (SCS) is a well-established therapy to address refractory persistent spinal pain syndrome after spinal surgery (PSPS-T2), its lack of spatial selectivity and reported discomfort due to positional effects can be considered as significant limitations. As alternatives, new waveforms, such as burst stimulation and different spatial neural targets, such as dorsal root ganglion stimulation (DRGS), have shown promising results. Comparisons between DRGS and standard SCS, or their combination, have never been studied on the same patients. "BOOST DRG" is the first prospective, randomized, double-blinded, crossover study to compare SCS vs. DRGS vs. SCS+DRGS. Sixty-six PSPS-T2 patients will be recruited internationally in three centers. Before crossing over, patients will receive each stimulation modality for 1 month, using tonic conventional stimulation. After 3 months, stimulation will consist in switching to burst for 1 month, and patients will choose which modality/waveform they receive and will then be reassessed at 6 and 12 months. In addition to our primary outcome based on pain rating, this study is designed to assess quality of life, functional disability, psychological distress, pain surface coverage, global impression of change, medication quantification, adverse events, brain functional imaging and electroencephalography, with the objective being to provide a multidimensional insight based on composite pain assessment.
Mots-clé
Cross-Over Studies, Ganglia, Spinal, Humans, Lower Extremity, Neuralgia/therapy, Prospective Studies, Quality of Life, Spinal Cord Stimulation, burst, energy consumption, failed back surgery syndrome, hybrid stimulation, leg pain, neurostimulation, refractory pain
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2022 11:35
Dernière modification de la notice
08/08/2024 6:31