Dexamethasone treatment increases neuropeptide Y levels in rat hypothalamic neurones

Details

Serval ID
serval:BIB_32A7AE507CD6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dexamethasone treatment increases neuropeptide Y levels in rat hypothalamic neurones
Journal
Life Sciences
Author(s)
Corder  R., Pralong  F., Turnill  D., Saudan  P., Muller  A. F., Gaillard  R. C.
ISSN
0024-3205 (Print)
Publication state
Published
Issued date
1988
Volume
43
Number
23
Pages
1879-86
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Immunoreactive glucocorticoid receptors (GR) have previously been demonstrated in neuropeptide Y (NPY) neurones of the rat hypothalamus. To determine whether NPY synthesis is influenced by glucocorticoids, the effect of dexamethasone (DEX) on the levels of immunoreactive NPY in rat hypothalamic neurones was investigated in vivo and in vitro. Daily injections of DEX (0.1 mg/day) for 5 days increased the NPY content of the mediobasal hypothalamus in female rats by 117% (p less than 0.002). Primary cultures of hypothalamic neurones were also sensitive to the effect of glucocorticoids. Intracellular NPY levels were significantly increased (p less than 0.001) compared to control values by 151%, 222% and 268% when cultures were maintained in a defined serum free medium containing DEX 10(-9), 10(-8) and 10(-7) M respectively.
Keywords
Animals Cells, Cultured Dexamethasone/*pharmacology Dose-Response Relationship, Drug Female Hypothalamus/drug effects/*metabolism Median Eminence/drug effects/metabolism Neurons/drug effects/*metabolism Neuropeptide Y/*metabolism Rats Rats, Inbred Strains
Pubmed
Web of science
Create date
25/01/2008 16:26
Last modification date
20/08/2019 13:18
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