Dexamethasone treatment increases neuropeptide Y levels in rat hypothalamic neurones

Détails

ID Serval
serval:BIB_32A7AE507CD6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dexamethasone treatment increases neuropeptide Y levels in rat hypothalamic neurones
Périodique
Life Sciences
Auteur(s)
Corder  R., Pralong  F., Turnill  D., Saudan  P., Muller  A. F., Gaillard  R. C.
ISSN
0024-3205 (Print)
Statut éditorial
Publié
Date de publication
1988
Volume
43
Numéro
23
Pages
1879-86
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Immunoreactive glucocorticoid receptors (GR) have previously been demonstrated in neuropeptide Y (NPY) neurones of the rat hypothalamus. To determine whether NPY synthesis is influenced by glucocorticoids, the effect of dexamethasone (DEX) on the levels of immunoreactive NPY in rat hypothalamic neurones was investigated in vivo and in vitro. Daily injections of DEX (0.1 mg/day) for 5 days increased the NPY content of the mediobasal hypothalamus in female rats by 117% (p less than 0.002). Primary cultures of hypothalamic neurones were also sensitive to the effect of glucocorticoids. Intracellular NPY levels were significantly increased (p less than 0.001) compared to control values by 151%, 222% and 268% when cultures were maintained in a defined serum free medium containing DEX 10(-9), 10(-8) and 10(-7) M respectively.
Mots-clé
Animals Cells, Cultured Dexamethasone/*pharmacology Dose-Response Relationship, Drug Female Hypothalamus/drug effects/*metabolism Median Eminence/drug effects/metabolism Neurons/drug effects/*metabolism Neuropeptide Y/*metabolism Rats Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
25/01/2008 17:26
Dernière modification de la notice
20/08/2019 14:18
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