Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.
Details
Serval ID
serval:BIB_324A0901D540
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.
Journal
Antimicrobial Agents and Chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
2014
Volume
58
Number
11
Pages
6958-6961
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax.
Keywords
Antimalarials/pharmacokinetics, Antimalarials/therapeutic use, Dihydropteroate Synthase/genetics, Drug Combinations, Drug Resistance/genetics, Genetic Markers/genetics, Genotype, Humans, Infant, Malaria, Falciparum/drug therapy, Malaria, Falciparum/parasitology, Malaria, Vivax/drug therapy, Malaria, Vivax/parasitology, Membrane Transport Proteins/genetics, Multidrug Resistance-Associated Proteins/genetics, Papua New Guinea, Plasmodium falciparum/drug effects, Plasmodium falciparum/enzymology, Plasmodium vivax/drug effects, Plasmodium vivax/enzymology, Protozoan Proteins/genetics, Tetrahydrofolate Dehydrogenase/genetics
Pubmed
Web of science
Open Access
Yes
Create date
02/09/2014 9:00
Last modification date
20/08/2019 14:17
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