Article: article from journal or magazin.
Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.
Antimicrobial Agents and Chemotherapy
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax.
Antimalarials/pharmacokinetics, Antimalarials/therapeutic use, Dihydropteroate Synthase/genetics, Drug Combinations, Drug Resistance/genetics, Genetic Markers/genetics, Genotype, Humans, Infant, Malaria, Falciparum/drug therapy, Malaria, Falciparum/parasitology, Malaria, Vivax/drug therapy, Malaria, Vivax/parasitology, Membrane Transport Proteins/genetics, Multidrug Resistance-Associated Proteins/genetics, Papua New Guinea, Plasmodium falciparum/drug effects, Plasmodium falciparum/enzymology, Plasmodium vivax/drug effects, Plasmodium vivax/enzymology, Protozoan Proteins/genetics, Tetrahydrofolate Dehydrogenase/genetics
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